Friday, 15 February 2019

Can a Pill Deliver Insulin through the Stomach??

Researchers have created a drug capsule that might be utilized to deliver oral doses of insulin, possibly replacing the injections that individuals with type 2 diabetes need to deliver themselves each day. About the size of a pea, the capsule contains a small needle made of compressed insulin, which is injected after the capsule reaches the stomach. In tests in animals, the researchers showed that they may deliver sufficient insulin to lower blood sugar to levels comparable to those produced by injections given through skin. They too illustrated that the device can be adapted to deliver other protein drugs.

Several years back, a pill coated with numerous tiny needles that can be utilized to inject drugs into the lining of the stomach or the small intestine was created. For the new capsule, the researchers changed the design to have just one needle, permitting them to avoid injecting drugs into the interior of the stomach, where they would be broken down by stomach acids before having any effect. The tip of the needle is made of about 100 percent compressed, freeze-dried insulin, utilizing the same process used to make tablets of medicine. The shaft of the needle, which does not enter the stomach divider, is made from another biodegradable material.

Within the capsule, the needle is attached to a compressed spring that is held in place by a disk made of sugar. When the capsule is engulfed, water within the stomach breaks down the sugar disk, releasing the spring and injecting the needle into the stomach wall. The stomach wall has no pain receptors, so the researchers accept that patients would not be able to feel the infusion. To guarantee that the drug is injected into the stomach wall, the researchers designed their system so that no matter how the capsule lands within the stomach, it can orient itself so the needle is in contact with the lining of the stomach. Once the tip of the needle is injected into the stomach wall, the insulin breaks down at a rate that can be controlled by the researchers as the capsule is ready. In this study, it took around an hour for all of the insulin to be completely discharged into the bloodstream.

After the capsule discharges its contents, it can pass harmlessly through the digestive framework. The researchers found no adverse impacts from the capsule, which is made from biodegradable polymer and stainless steel components. The team is presently proceeding to work further to create the technology and optimize the manufacturing process for the capsules. They believe this type of drug delivery can be useful for any protein drug that ordinarily must be injected, such as immune-suppressants used to treat rheumatoid joint pain or inflammatory bowel disease. It may too work for nucleic acids such as DNA and RNA.

Sunday, 27 January 2019

Long-acting contraceptive designed to be self-administered via microneedle patch

Scientists have outlined a novel long-acting contraceptive that can be self-administered by women employing a painless microneedle skin patch. The researchers clear the way for a new family planning choice, especially in developing countries where access to healthcare can be constrained. Long-acting contraceptives presently available provide the highest level of effectiveness, but ordinarily, require a healthcare professional to inject a drug or implant a gadget. Short-acting methods, on the other hand, require frequent compliance by users and so are regularly not as effective. Initially planned for utilizing in zones of the world with restricted access to health care, the microneedle contraceptive might possibly give a new family planning alternative to a broader population.

In animal testing, an experimental microneedle contraceptive patch gave a therapeutic level of contraceptive hormone for more than a month with a single application to the skin. When the patch is connected for a few seconds, the microscopic needles break off and remain beneath the surface of the skin, where biodegradable polymers gradually discharge the contraceptive drug levonorgestrel over time. Because the tiny needles must stay within the skin for the time-release of the hormone, researchers created a mechanical strategy that would permit the drug-containing microneedles to break free from the patch's backing material. To achieve that, the researchers molded tiny air bubbles into the top of the microneedles, making an auxiliary weakness. The resulting microneedles are solid sufficient to be squeezed into the skin, but when the patch is then moved to one side, the shear force breaks off the tiny structures within the skin. The patch backing can then be discarded.

Long-acting contraceptives are presently accessible in formats such as patches that must be worn persistently, intrauterine devices (IUDs) that must be set by trained healthcare experts, and drugs infused with hypodermic needles. The microneedles are molded from a blend of biodegradable polymers, poly (lactic-co-glycolic corrosive) and poly(lactic corrosive), commonly utilized in resorbable sutures. In case the microneedle contraceptive fix is eventually approved for use, it might become the primary self-administered, long-acting contraceptive that does not involve a conventional needle injection, researchers said. The researchers aim to develop a patch that can be applied once each six months. The contraceptive would be conveyed using microneedle skin patch innovation initially created for the painless administration of vaccines. Like other long-acting contraceptive methods, the microneedle contraceptive patch would disturb the menstrual cycles of women utilizing it.

Thursday, 24 January 2019


About Conference

2nd Global Physicians and Healthcare Congress which is going to be held on June 13-14, 2019 in Helsinki Finland, provides a great opportunity to interact with the world’s most leading physicians, doctors and healthcare professionals. The theme of the conference is “Discover the Wellness and get answers about your Health”. This conference will also have a wide range of showcase of exhibitors, collaborators for you to explore. Professionals and Leading physicians who will be attending the conference and will also examine a wide range of innovative scientific development and advances in Medical and Healthcare research from basic science to clinical research.

Physicians Congress 2019 will become a wide platform to learn and perform research on the latest advancements in the field of Medical and Healthcare which will be useful to High professional doctors, researchers, physicians and healthcare professionals. Generally medicine deals with the prevention and cure, diagnosis, and treatment of adult diseases. Professionals specializing in general medicine are called internists, or physicians. Physicians or Doctors are skilled in the management of patients who have undifferentiated or multi-system diseases. Physicians mostly have subspecialty and many special interests in diseases that are affecting different organs in the body.

Target Audience:

  • Healthcare professionals
  • Physicians
  • Cardiologists
  • Deans of Medical Universities and Institute
  • Physiatrists
  • Paediatricians
  • Naturopathic Doctors
  • Allopathic Doctors
  • Oncologists
  • Nephrologists
  • Orthopaedic Surgeons
  • Physiotherapists
  • Neurologists
  • Urologists
  • Psychologists
  • Gynaecologists
  • Haematologists
  • Gastroenterologists
  • Dietician
  • Medical Professionals
  • Business Entrepreneurs
  • Medical devices Companies
  • Biomedical companies
  • Pharmaceutical companies

Conference Highlights

Friday, 27 April 2018

New insights in Precision Medicine

Personalized Medicine is also known as Genomic Medicine or Precision Medicine, this method is used in which the disease risks are different and unique. The disease risks are based on the pre- dispositions printed into the genome at the time of birth, environment and combined with the lifestyle. It also considered as an extended traditional approach to understand and treat the disease with greater accuracy/precision. Gene variations in a patient’s profile can guide the selection of drugs or treatment protocols which minimizes harmful effects. Personalized Medicine can also indicate a person’s susceptibility to certain diseases before they become the onset of the disease which allows physicians to design and plan for monitoring and prevention.

Personalized Medicine works best with the network of electronic health data that links clinical.
Although we have known SNPs for almost two decades however, revealing their utility has proven extremely difficult as barcodes. Every individual carry 10 million genetic variations in our genome which is called as single nucleotide polymorphisms SNPs, which signify a difference of one letter that is single nucleotide differs in the genetic code. Every individual’s pattern of SNPs is quite stable and unique. Theses SNP’s are inherited, rarely mutated which making them Natural barcode.
 Recent studies show the Natural barcode which enable better understanding in cell tracking from any individual.

Join us for the most advanced talks and keynote sessions at “Global Physicians and Healthcare Congress

Thursday, 5 April 2018

What compels people to going under the Knife??? Bariatric Surgery!!!!!!

Obesity is one of the major nutrition-related disorders. Traditional nutrition research has associated various foods and nutrients with obesity. The importance of nutrition in prevention and treatment of obesity has gained much attention from public health professionals. Good nutrition, a healthy body weight and physical activity are vital parts of a person’s overall health and well-being.
Obesity is generally measured in body mass index, a person having a body mass index of 30 or more is known to be obese.  Body mass index it is a measure of relation between Height and Weight of a person. There are 3 class of obesity: Class 1 obesity having Body mass index of 30 to 35, Class 2 has 35 to 40 and Class 3 has 40 or more.
And the last 2 Classes are hard to treat with diet and exercise alone, in this case surgery is needed.
Weight loss surgery is also known as Bariatric Surgery.  Bariatric surgery is an operation which helps to lose weight by making alteration to the digestive system.

“A Life time commitment is needed to improve the health and maintain healthy habits”

  • Laparoscopic - Gastric Band: A ring with an inner expandable band around the top of the stomach is placed to create a small pouch. This will give a fuller feeling after eating a small quantity of food.
  • Gastric Sleeve: It is also called as vertical sleeve gastrectomy. In this procedure most of the stomach is removed leaving the banana-shaped section which is closed with staples. Even this will give a fuller feeling after eating a small quantity of food.
  • Gastric Bypass: It is called as Roux-en-Y gastric bypass which has two parts. The first part is to staples the stomach by creating a small pouch in the upper section. And next step is to cuts the small intestine and attaches the lower part of it directly to the small stomach pouch. Through this bypass the body absorbs less calories and feel full sooner.
  • Gastric Balloon
  • Duodenal Switch
  • AspireAssist
  •  vBloc Therapy

All these types of bariatric surgeries make the stomach smaller, permitting to eat and drink lesser amounts at one time and making feel full sooner.

Regular physical activity after the surgery will help to keep the weight off. To get the latest updates and share your thoughts on Obesity and Nutrition - Join us for the advance Talks/Sessions at Physicians Congress 2018.

Saturday, 24 March 2018

Reminder to the world The most threatful disease in the World - TB is a curable disease!!!!!

Infectious diseases are generally caused by pathogenic microorganisms such as viruses, bacteria, parasites or fungi. The disease can be spread through directly or indirectly contact from one person to another. Animals infectious diseases are known as Zoonotic diseases which can be transmitted to humans. Many infectious diseases can be prevented by vaccines. Infectious diseases are one of the main leading causes of death’s worldwide. Most of the diseases become difficult to control if the infectious agents develop resistance to commonly used drugs.

Mycobacterium tuberculosis, causative agent of tuberculosis which is one of the deadliest diseases and approximately 2 billion people are affected annually in the world. About 1/3 rd of world’s population has latent tuberculosis infection. TB being a curable disease, remains one of the top 10 causes of death worldwide.

Treatment of TB:

More than twenty drugs available for treatment of tuberculosis. Which are usually used in different combination. Few tuberculosis drugs are exclusively used for the treatment of new patients with no drug resistance they are known as first line drugs. Second line drugs are only used for the treatment of drug resistant tuberculosis. Drug susceptible tuberculosis i.e. (TB which is not drug resistant) is usually cured in 6 months using a combination of first line TB drugs.

Surgical interventions which may help to treat MDR-TB (Multidrug-resistant), TDR-TB (Totally drug-resistant) and XDR-TB (extremely drug-resistant). In that case one should take a surgical opinion if there is no improvement even after six months of Drug-sensitive Anti Tubercular Treatment or medications.

Reasons behind the failure of TB treatment:

Mainly because of Patients not taking drugs properly and lack of money for treatment. Doctors are not providing the appropriate guidelines, Non-compliance with guidelines and Absence of guidelines which leads to failure of the treatment. And lastly due to poor quality of drugs, wrong delivery system of drugs.

Global Physicians and Healthcare Congress” provides a platform for advanced research in the field of healthcare and medical. Share your ideas at our upcoming conference in June 2018. 

Can a Pill Deliver Insulin through the Stomach??

Researchers have created a drug capsule that might be utilized to deliver oral doses of insulin, possibly replacing the injections that in...